Margot scored her first big TV role through typical Aussie grit. Determined to land a part on the legendary Australian soap, Neighbours, she called the production company every day. "One day, I got put through, by accident to the casting director," she later recalled, and the rest is history. In June 2008, at the age of 17, Margot took up the role of schoolgirl Donna Freedman. The role was supposed to be a guest character, but Margot went on to play her for three years, even returning for the show's finale in 2022.